Risk of coeliac disease in children of patients and effect of HLA genotype.
نویسندگان
چکیده
Among 73 offspring of parents with coeliac disease, 4 were affected, including 1 in whom the diagnosis was made as a result of the study. The coeliac parents of all 4 were HLA-B8 positive, but 1 affected child had failed to inherit his affected parent's B antigen. The findings are consistent with the hypothesis that an allele affecting liability to coeliac disease is in linkage disequilibrium with HLA-B8.
منابع مشابه
Coeliac screening in a Scottish cohort of children with type 1 diabetes mellitus: is DQ typing the way forward?
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ورودعنوان ژورنال:
- Journal of medical genetics
دوره 15 1 شماره
صفحات -
تاریخ انتشار 1978